A new investigational drug, MSDC-0160, originally developed for type 2 diabetes is being readied for human clinical trials in search of the world’s first treatment to impede the progression of Parkinson’s disease following publication of research findings in the journal Science Translational Medicine. “Until now, Parkinson’s treatments have focused on symptom management. If successful in…
neuroprotection
Candidate Parkinson’s Drug Advances to Phase 3 Trial
The Michael J Fox Foundation has reported today, 1st September 2015, that researchers testing the compound inosine for its effect on Parkinson’s progression have funding from the National Institutes of Health for a Phase III trial, the last step before regulatory approval. Inosine is a precursor to the antioxidant of urate. The Michael J. Fox…
New growth factor indicates possible regenerative effects in Parkinson’s disease
Science Today reports that researchers at Lund University and Karolinska Institutet have, in a first-in-human clinical study with twelve participating patients, applied a growth factor to the brain with the hope of preserving dopaminergic cells and fibres. The growth factor, PDGF (platelet-derived growth factor), has previously demonstrated, in studies in animals with Parkinson-like symptoms, reparative…
Drug candidates may block cell death in Parkinson’s disease
Science Daily reports that in a pair of related studies, scientists from the Florida campus of The Scripps Research Institute (TSRI) have shown their drug candidates can target biological pathways involved in the destruction of brain cells in Parkinson’s disease. The studies, published in the Journal of Medicinal Chemistry and Scientific Reports, suggest that it…
Phase III trial of Israpidine
Researchers at the University of California, San Diego School of Medicine have launched a Phase III clinical trial to evaluate the drug isradipine, a calcium channel blocker often used to treat high blood pressure, as a potential new treatment for Parkinson disease (PD). The goal of the study is to determine whether the drug can…
PBT434 Drug Shows Promise
Researchers at the University of Leeds are one step closer to developing a new treatment for Parkinson’s, thanks to a £150,000 research grant from Parkinson’s UK. This new research will allow Dr James Duce and his team to investigate whether a drug known as PBT434 that targets iron may have potential as a new and…